Iowa State Cyclones dynasty and here is a weird strategy i do; when playing against the computer and their in 3rd and 10 or longer. I sub a LB or S for my DT and run a nickel or dime with 3 lineman, but take user control of my "DT" and just kinda roam around looking for a pick. The computer doesn't like to throw the ball deeper than 15 yards on me anyway it seems, even on heisman or the other "tough" levels.
Only other team I ever play as is Arizona State.
Love the game on the 360, only gripe is that if you don't touch the game sliders at all, it seems like the computer can throw for 200-300 yds on me, but only run for about 20.