| Date (Time) | Schedule | Location | TV | Results |
|---|---|---|---|---|
| Sept. 1 (7 p.m.) | South Dakota State | Jack Trice Stadium | Cyclones.tv | Cancelled |
| Sept. 8 (4 p.m.) | Iowa | Iowa City, Iowa | FOX | L, 3-13 |
| Sept. 15 (11 a.m.) | Oklahoma | Jack Trice Stadium | ABC/ESPN/ESPN2/ESPNU | L, 27-37 |
| Sept. 22 (11 a.m.) | Akron | Jack Trice Stadium | FSN | W, 26-13 |
| Sept. 29 (6 p.m.) | TCU | Fort Worth, Texas | ESPNU | L, 17-14 |
| Oct. 6 (2:30 p.m.) | Oklahoma State | Stillwater, Okla. | ESPN2 | W, 48-42 |
| Oct. 13 (6 p.m.) | West Virginia | Jack Trice Stadium | FS1 | W, 30-14 |
| Oct. 27 (TBA) | Texas Tech (HC) | Jack Trice Stadium | TBA | |
| Nov. 3 (TBA) | Kansas | Lawrence, Kan. | TBA | |
| Nov. 10 (TBA) | Baylor | Jack Trice Stadium | TBA | |
| Nov. 17 (7 p.m.) | Texas | Austin, Texas | Longhorn Network | |
| Nov. 24 (TBA) | Kansas State | Jack Trice Stadium | TBA |
