| Date | Time | Opponent | Location | Score | Media |
|---|---|---|---|---|---|
| 11.5.19 | 7:00 P.M. | Mississippi Valley State | Ames, Iowa | W 110 - 74 | Cyclones.TV |
| 11.9.19 | 3:30 P.M. | Oregon State | Corvallis, Ore. | L 74 - 80 | PAC-12 Network |
| 11.12.19 | 7:00 P.M. | Northern Illinois | Ames, Iowa | W 70 - 52 | Cyclones.TV |
| 11.19.19 | 7:00 P.M. | Southern Miss | Ames, Iowa | W 73 - 45 | Cyclones.TV |
| 11.27.19 | 11:00 A.M | Michigan | Paradise Island, Bahamas | L 83 - 76 | ESPN |
| 11.28.19 | TBA | Alabama | Paradise Island, Bahamas | W 104 - 89 | TBA |
| 11.29.19 | TBA | Seton Hall | Paradise Island, Bahamas | L 84 - 76 | TBA |
| 12.4.19 | 7:00 P.M. | Kansas City | Ames, Iowa | W 79 - 61 | Cyclones.TV |
| 12.8.19 | 8:00 P.M. | Seton Hall | Ames, Iowa | W 76 -66 | ESPN2 |
| 12.12.19 | 7:00 P.M. | Iowa | Ames, Iowa | L 68 - 84 | ESPN2 |
| 12.22.19 | Noon | Purdue Fort Wayne | Ames, Iowa | W 89 -59 | Cyclones.TV |
| 12.31.19 | 6:00 P.M. | Florida A&M | Ames, Iowa | L 68-70 | Cyclones.TV |
| 1.4.20 | 5:00 P.M. | TCU | Fort Worth, Texas | L 79 - 81 | ESPN2/U |
| 1.8.20 | 7:00 P.M. | Kansas | Ames, Iowa | L 53 - 79 | Big 12 Now/ESPN+ |
| 1.11.20 | 7:00 P.M. | Oklahoma | Ames, Iowa | W 81 - 68 | ESPN/2 |
| 1.15.20 | 7:00 P.M | Baylor | Waco, Texas | L 55 - 68 | Big 12 Now/ ESPN+ |
| 1.18.20 | 3:00 P.M. | Texas Tech | Lubbock, TX | L 52 - 72 | ESPN/2/U |
| 1.21.20 | 7:00 P.M. | Oklahoma State | Ames, Iowa | W 89 - 82 | Big 12 Now/ESPN+ |
| 1.25.20 | 11:00 A.M. | Auburn | Auburn, Alabama | L 76 - 80 | ESPN/2/U |
| 1.29.20 | 8:00 P.M. | Baylor | Ames, Iowa | L 53 - 67 | ESPN2/U |
| 2.1.20 | 1:00 P.M. | Texas | Austin, Texas | L 68 - 72 | Longhorn Network |
| 2.5.20 | 6:00 P.M. | West Virginia | Morgantown, W.V. | L 61 - 76 | ESPN2/U |
| 2.9.20 | 7:00 P.M. | Kansas State | Ames, Iowa | W 73 - 63 | ESPN2 |
| 2.12.20 | 8:00 P.M. | Oklahoma | Norman, OK. | L 61 - 90 | ESPN2/U |
| 2.15.20 | 1:00 P.M. | Texas | Ames, Iowa | W 81 - 52 | ESPN2 |
| 2.17.20 | 8:00 P.M. | Kansas | Lawrence, KS | L 71 - 91 | ESPN |
| 2.22.20 | 5:00 P.M. | Texas Tech | Ames, Iowa | ESPN/2/U | |
| 2.25.20 | 6:00 P.M. | TCU | Ames, Iowa | ESPNU | |
| 2.29.20 | 3:00 P.M. | Oklahoma State | Stillwater, OK. | ESPN/2/U | |
| 3.3.20 | 8:00 P.M. | West Virginia | Ames, Iowa | ESPN2/U | |
| 3.7.20 | 8:00 P.M. | Kansas State | Manhattan, KS | Big 12 Now/ ESPN+ | |
| 3.11-3.14.20 | TBA | Big 12 Tournament | Kansas City, MO | TBA |