| Date | Time | Opponent | Location | Score | Media |
|---|---|---|---|---|---|
| 11.5.17 | 5:00 P.M. | Emporia State (Exhibition) | Hilton Coliseum | (W) 77-68 | Cyclones.tv |
| 11.10.17 | 8:00 P.M. | Missouri | Columbia, Mo. | (L) 74-59 | SEC Network |
| 11.13.17 | 7:00 P.M. | Milwaukee | Hilton Coliseum | (L) 74-56 | Cyclones.tv |
| 11.16.17 | 4:30 P.M. | Appalachian State (Puerto Rico Tip-Off) | Conway S.C. | (W) 104-98 | ESPNU |
| 11.17.17 | 6:00 P.M. | Tulsa (Puerto Rico Tip-Off) | Conway, S.C. | (W) 80-78 | ESPNU |
| 11.19.17 | 6:30 P.M. | Boise State | Conway, S.C. | (W) 75-64 | TBA |
| 11.25.17 | 7:00 P.M. | Western Illinois | Hilton Coliseum | (W) 70-45 | Cyclones.tv |
| 12.4.17 | 8:00 P.M. | Northern Illinois | Hilton Coliseum | (W) 94-80 | Cyclones.tv |
| 12.7.17 | 7:00 P.M. | Iowa | Hilton Coliseum | (W) 84-78 | ESPN2 |
| 12.10.17 | 5:00 P.M. | Alcorn State | Hilton Coliseum | (W) 78-58 | Cyclones.tv |
| 12.16.17 | 3:30 P.M. | Northern Iowa (Hy-Vee Classic) | Des Moines, Iowa | (W) 76-65 | MC22 |
| 12.20.17 | 6:00 P.M. | Maryland Eastern Shore | Hilton Coliseum | (W) 55-49 | Cyclones.tv |
| 12.29.17 | 8:00 P.M. | Kansas State | Hilton Coliseum | (L) 91-75 | ESPNU |
| 1.1.18 | 6:00 P.M. | Texas | Hilton Coliseum | (L) 74-70 (OT) | ESPNU |
| 1.6.18 | 3:00 P.M. | Oklahoma State | Stillwater, Okla. | (L) 96-87 (OT) | ESPNU |
| 1.9.18 | 8:00 P.M. | Kansas | Lawrence, Kan. | (L) 83-78 | ESPN2 |
| 1.13.18 | 2:00 P.M. | Baylor | Hilton Coliseum | (W) 75-65 | ESPNEWS |
| 1.17.18 | 8:00 P.M. | TCU | Fort Worth, Texas | (L) 96-73 | ESPNU |
| 1.20.18 | 1:00 P.M. | Texas Tech | Hilton Coliseum | (W) 70-52 | ESPNU |
| 1.22.18 | 6:00 P.M. | Texas | Austin, Texas | (L) 73-57 | ESPNU |
| 1.27.18 | 3:00 P.M. | Tennessee | Hilton Coliseum | (L) 68-45 | ESPNU |
| 1.31.18 | 6:00 P.M. | West Virgnia | Hilton Coliseum | (W) 93-77 | ESPNU |
| 2.3.18 | 7:00 P.M. | Baylor | Waco, Texas | (L) 81-67 | ESPN2 |
| 2.7.18 | 8:00 P.M. | Texas Tech | Lubbock, Texas | (L) 76-58 | ESPNU |
| 2.10.18 | 1:00 P.M. | Oklahoma | Hilton Coliseum | (W) 88-80 | ESPN2 |
| 2.13.18 | 6:00 P.M. | Kansas | Hilton Coliseum | ESPN2 | |
| 2.17.18 | 12:00 P.M. | Kansas State | Manhattan, Kan. | ESPNU | |
| 2.21.18 | 7:00 P.M. | TCU | Hilton Coliseum | Cyclones.tv | |
| 2.24.18 | 5:00 P.M. | West Virginia | Morgantown, W.V. | ESPN/ESPN2 | |
| 2.27.18 | 6:00 P.M. | Oklahoma State | Hilton Coliseum | ESPNU | |
| 3.2.18 | 8:00 P.M. | Oklahoma | Norman, Okla. | ESPN2 | |
| 3.7.18-3.10.18 | TBA | Big 12 Men's Basketball Championship | Kansas City, Mo. | TBA |