-Es Tas in Campustown is both a good bar, and a good place to get a bite to eat. My favorite tacos on the planet.
-As far as bars, what are you gals looking for? Here are some popular bars and their vibes
1) Chasers: cheap beer at most hours. Ok music (mix of modern rock/90s rock/and rap).
2) Mickey's: typical "Irish" pub. Usually a pretty good time
3) Paddy's: see above.
4) Capone's: more focused on live music, usually a pretty good party atmosphere.
5) Headliner's: haven't made it there much since it reopened, but it used to be home to People's and Lumpy's, two of the greatest bars Ames has ever seen.
6) Outlaw's: dust off your cowboy boots. This is the "country" bar. Lot's of dancing.
7) Element: Skeezy dance club. All rap. You practically get an STD walking through the door.
8) Sgt. Pepper's: a good straight up drinking bar that places great tunes (all classic rock). Throw peanut shells on the floor all night and get pretty lit up.
These aren't all the bars, but it gives you a good starting point. All of these bars are located in the Campustown area. Also, as far as food goes, I'd recommend all the places that have been listed (except Applebees) and add the West St. Deli (great deli sandwhiches) Fighting Burrito (like Chipotle but better) Jeff's Pizza (beyond delicious and slices are available at most times), La Fuente (well done, but pretty standard Mexican) and Battle's BBQ (apparently it's back in business?).
Where are you staying? Odds are you'll be able to take the Cy-Ride Moonlight Shuttle (aka the Drunk Bus) home from the bars. Enjoy Ames!