I'm a big fan of in-line engines. Of course, I do as much maintenance as I can myself, and convenience of maintenance is the big sell for me.
For most V-6 front-drive cars, the back spark plugs are mythical, because there is no way in heck you'll ever get to them.
As far as 4-banger trucks are concerned, I don't know anyone who has a brain that would call the Toyota 22RE a "joke". Likewise with the 4 cylinder jeeps and diesel engines.
Show me a car that is "underpowered" and I'll show you an incompetent driver. I spent 2 years in the Bavarian Jura mountains with a 70 hp Opel sedan, and I got along just fine. Of course, I'm a competent driver, and have the ability to think so that I can keep ahead of my car.