Not gonna happen.
Beginning in 2017 Iowa will go to a 9th conference game. Replace North Dakota State with Michigan State and the schedule gets a lot tougher not just in terms of wins but the risk of injuries increases.
Twice in the last 10 years Iowa finished with 6 wins. Subtract one of the soft non-conference wins and replace it with a loss due to a 10th power 5 game and they don't make a bowl game. There could be pressure from both sides to end the series.
Take a look at how Pinkel built Missouri. Most ISU fans remember Missouri being a doormat - 15 consecutive losing seasons. When Pinkel got the job he paid a financial penalty to back out of a 4 game series with none other than Iowa because Pinkel wanted to be bowl eligible. Missouri's 4 non-conference games this year feature zero power 5 schools. If Pinkel had to play 10 power 5 opponents a year he would never have made it through his first 5 years. It isn't just Pinkel, most of the SEC coaches would never be in favor of a 9th conference game plus a power 5 non-conference opponent.
Bowl games are fun for the fans and attract recruits. How many recruits did ISU get because of the Iowa game?