From a financial standpoint, more money in your pocket is better than money out of your pocket. So meaning, it is better to owe taxes in the end rather than getting a refund. As others have said, if you invest the money throughout the year that would have otherwise been used for your refund, you would end up with a small gain on the money. So if you were to keep $1000 during the year that would have been used for a refund and invested it in in a bond fund earning 3.5%, you'd end up with $35 more by the end of the year as opposed to nothing if you got a refund.
On the flip side, a refund is a way to save money throughout the year as you won't be able to spend it until you receive the refund. However, this works so long as you put the money into savings as opposed to spending it right away.
I have a degree in finance, and I always shot for getting a refund. However this year, I will owe some taxes due to the changes in the tax rules.
Having said all that, do what is best for you. There was a guy on here said that he used to always get a refund but then changed to owing taxes due to an issue on his taxes. From what I can recall, he stated he was owed a bigger refund than what the government was showing. since it was a refund, he felt the government was not trying too hard to review his tax returns. He felt that if he owed money and there was an issue with his taxes, they would try hard to fix.