Home conference losses by year:
2010-2011: Throw away year
2011-2012: Missouri (8-1 home, 4-5 road)
2012-2013: Kansas (8-1 home, 3-6 road)
2013-2014: Kansas (8-1 home, 3-6 road)
2014-2015: Baylor (8-1 home, 4-5 road)
2015-2016: Baylor, WVU (7-2 home, 3-6 road)
2016-2017: Kansas (8-1 home, 4-5 road)
2017-2018: Throw away year
2018-2019: KSU, TCU (4-2 home, 3-2 road)
Still very possible to win out at home and the only game I would say is a likely loss is @KSU. I would no question take 12-6 or 11-7.
If you told me Iowa State would start 2 freshman who play a bunch of minutes and Wigginton would struggle and we'd have double digit conference wins there isn't a person here who wouldn't have made that deal.