I think most of you are focusing too much on the number of starters other teams are losing. To be fair, the media also focuses too much on this. For instance, KU lost only two defensive players (both starters) on the two-deep from it's outstanding 2007 defense to 2008, but undoubtedly got much worse. On the other hand, KU lost half of their offensive starters from '07 to '08, but hummed along just fine.
Assuming good coaching (and now that Ron Prince is out of the Big XII, I think everyone in the league has it), and unless they are replacing elite players (Jeremy Maclin is going to be hard to replace; Nate Swift shouldn't be as hard, etc.), it's not too hard to find an adequate replacement for most starters.
I think our focus when predicting next season should instead be on our own team, which for some reason is talked about a lot less on this board than other teams' losses. I think our offense should be fine; we have good young players all over the field. However, our defense was not good last year (notwithstanding the Iowa game and the 1st half of the KU game). And I don't see many players who can get us to the level we need to be to consistently win games. If LJ can take the next step and become a lockdown corner who we can roll coverage away from, and if we can get some consistent pressure on the QB (Chris Lyle looks like he could take the next step and be a consistent force in the backfield), then we could be a decent defensive team. Going off of what we saw last year on defense, though, I'm not sure how people are predicting that we win half our games this year, despite the fact that we lost our last ten games. Add the fact that coaching changes rarely generate more wins in year 1, and I don't see us winning any more than 3-4 games.