If they play their game they won't be losing until the Sweet 16. They are likely to be a #1 seed so I doubt they "slip by" the 16 seed in the 1st round. They have a huge advantage in having 2 go-to low post scorers. If Self wants to be, they can be drought proof, which is crucial in the dance. They also have better athletes at nearly every position than 99% of teams in CBB, if Self decides to, they can lock down pretty much anyone on the defensive end and create a ton of turnovers. Credit where credit is due, they're a good team with an even better upside.
A team that could beat them would be a veteran, tournament tested team, which there aren't many of out there to come up against.