Let the amazing ISUCyclones2015 help you. Take 80 East to 77 South then to wherever. 74 to Salem 40 to Greensboro etc etc. The only construction you will hit is in Joliet, Illinois which can be avoided by taking 88 over to Chicago then 294 down to 80. And also in Western Ohio which can't be avoided but it isn't nearly as bad as the construction in Indy and Dayton. Or if you're taking the Cincy route, that sucks too.
My way, you can stop and see things like Chicago, South Bend, Cleveland (Rock and Roll Hall of Fame), Canton (Pro Football Hall of Fame), Coshocton (really cool Erie Canal city and just awesome history), Marietta (same as Coshocton but on the Ohio River), the West Virginia Turnpike which is a blast to drive 65-75mph. And Parkersburg is pretty cool too.