Two things to add. E85 even with half the BTUs is capable of far better mileage. However, it would require a much higher compression engine to take advantage of it's properties which would make it incompatible with gasoline. They're working on variable compression engines. If they ever figure it out, it would be a game changer.
The other is that variable cylinder technology, turbos, and other things which have added marginal efficiency to economy thus far have been sadly unreliable. Things which were almost a thing of the past such as oil consumption are now commonplace again. Any money that has been saved in fuel economy has been wasted in long term repair costs. And I would argue wasted at an exponential level.
Oh, and one more thing. Honda's are designed for a 20 year/200k lifecycle. I would assume most cars today are. But this extra crap on them is not helping reliability one bit.
I would figure 200K miles to be less than 10 years of life.