Will the starters go 35+ minutes today while we are up 95-46?
Probably. I don't know why you and others keep getting hung up on this. Nobody played more than 25 last game so 35 is another exaggeration. And if you're worried about injuries, I guess they should just not play, practice or walk up the Hilton stairs either.
They don't have a game for over a week and they'll be needed for a full game so they likely need to play like it. Before someone says they can just run in practice, game conditioning is a completely different thing than just running at practice.
Not to mention imo ISU hasn't really played all that well the last few games and I'd guess they have some things to work on for consistency/maintaining intensity.