The only way I can see ISU getting Des Moines first-weekend and placed in KC region is climbing to a 1 seed (or maybe a 2 seed, if stars align). We're a long way from that. But as CW said, it's daydreaming, no big deal.
Pretty sure a 2 seed would be a high probability of Des Moines. The biggest factors are how high Michigan and Michigan St are. If they are ahead of us, we need them to take the Columbus locations. Des Moines would be the second choice for both of them.
DSM would be the 1st choice for Wisconsin, Marquette
DSM would be the 1st or 2nd choice for Kansas.
DSM would be the 2nd choice for MSU, Michigan, Purdue, Texas Tech
DSM would be the 3rd choice for Kentucky, Louisville
If Iowa State would be a 2 seed, things would have to go wrong for them to not get DSM. Something like this would have to happen which is plausible.
1. Tennessee (Columbia)
2. Duke (Columbia)
3. Kentucky (Columbus)
4. Virginia (Columbus)
5. Michigan (DSM)
6. Michigan St (DSM)
7. Iowa State (Tulsa)
This is the best I could do, realistically, to get Iowa State to DSM.
1. Tennessee (Columbia)
2. Virginia (Columbia)
3. Michigan St. (Columbus)
4. Gonzaga (Salt Lake City)
5. Michigan (Columbus)
6. Duke (Jacksonville)
7. North Carolina (Jacksonville)
8. Virginia Tech (Hartford)
9. Houston (Tulsa)
10. Kansas (Tulsa)
11. Kentucky (DSM)
12. Nevada (Salt Lake City)
13. Iowa State (DSM)
It is a crazy stretch to think Iowa State could get there as a 4 seed. I'd say 50/50 if they are a 3 seed and probably an 80% chance if they are a 2 seed.