Never in the history of the NCAA Tournament has a 16th seed knocked off a 1 seed. This year, I think that trend continues. However, out of all the number one seeds which one would be the most vulnerable? I am not picking it, but I think the number one seed that COULD be the most vulnerable to have this happen is Virginia. Coastal Carolina in my opinion is the strongest number 16 seed and will keep this contest relatively close. Your thoughts?