Rest, rest and more rest. Aspirin, tylenol, ibuprofin for sore throat, body aches & fever. Mono is viral...antibiotics are useless (unless you have strep throat concurrent with the mono like my son did).
Found this - it's a pretty good coverage.
MONO TREATMENT
The goal of mono treatment is to ease the symptoms while the immune system contains the initial viral infection. Antibiotics are not helpful because mono is caused by a virus and there are no antiviral medications that can treat or cure EBV.
Pain and fever — Sore throat, muscle aches, and fever can be treated with non-prescription medications, such as acetaminophen (Tylenol® and others) or ibuprofen (Motrin®, Advil®). Acetaminophen is broken down by the liver. Thus, it is important to closely follow the dosing instructions or your healthcare provider's instructions to safely take this medication. Acetaminophen and ibuprofen are also recommended for use in children. Aspirin should not be given to young children with mono because of possible liver complications.
Rest — Mono can cause severe fatigue, although most people recover within two to four weeks. For some, significant tiredness lasts for weeks to months. Early in the infection, it is important to get adequate rest, although complete bed rest is not necessary.
Diet — Feeling ill often causes a loss of appetite. This is normal, and usually improves as the infection improves. It is important, even if you have no appetite, to drink an adequate amount of fluids. This is especially true if you are taking ibuprofen for pain or fever because ibuprofen can affect kidney function if you become dehydrated. You are drinking adequate fluids if your urine is a pale yellow color.
WHEN CAN I GO BACK TO WORK OR SCHOOL?
Many people with mono develop an enlarged spleen, which can last for a few weeks or longer. Although you can return to school or work when you are feeling better, it's important to avoid activities that can cause injury to the spleen.
Experts generally recommend that athletes not participate in sports activities for at least the first three to four weeks of the illness [
1]. Your healthcare provider should determine when it is safe for you to participate in strenuous activities or contact sports.
When you do begin participating in sports activities again, we recommend starting slowly, increasing activity gradually. Even highly trained athletes may not feel as fit after having mono as they did before the illness.
