I do what you suggest frequently when ISU is favored in games that matter, but I think I'm going to do a WVU + ISU tease today. Will have to win both of ISU +3 and WVU + 10. I have to think that the ISU line is pretty depressed after their last several performances. I believe in mean reversion so hoping ISU can surprise to the upside.
WVU +6 at home against OU seems like a strange line. I'd imagine OU won't struggle against their press, and that is likely what the line reflects, but still!
Note: I am not a winning sports better, so this is not advice. You'd probably be better off doing the opposite of whatever I do.