The 3.8 with a supercharger is one of the most reliable cars I've ever seen. I had a GTP. Yeah the computer doesn't stop you from doing anything stupid, but I would be pissed if it did. I sold the car to my dad and he beats the crap out of it. He owns a construction company and drives it to work sites, down gravel roads, wherever. At 100,000 miles it's going strong with only tires and brakes.
As for Detroit pumping out crap I'd put my GTO or Cadillac V against anything listed so far. The GTO is technically Aussie, but at least GM had the good sense to bring it over here. I go through a lot of cars and the V is the first I've ever wanted to keep longer than a year.
The GTO is an awesome car. It's a re-badged Holden Monaro, however, and they just killed it off. It's one of the few "big 3" cars I would have considered, but it's hardly a "detroit" car. I drive a lot of new Big 3 cars since I travel a fair bit and have a lot of rental cars. I haven't driven a single car or truck from any of the Big 3 that I would consider purchasing myself in the last 4 or 5 years.
I've never actually been in physical pain driving a car until I drove a 07 Ford Taurus a year or so back. After 45 minutes I had to physically get out of the vehicle because my legs were cramping so bad.
I had a Saturn ion with 10,000 miles on it a month or two ago that felt as though I was driving a dump truck. It felt like it had turbo lag, but it was just because it had no torque low in the power band, apparently. The steering wheel had a good 5 degrees of free travel on either side of the center, and it had so much body sway going around corners, I was afraid it was going to roll sometimes. I won't even get into interior trim quality, or how things 'felt' (in short, as if someone had crashed a Daewoo into a Tonka truck factory).
I hear repeated horror stories from almost everyone I know that has a piece of "Detroit" iron (which was likely built in Mexico). My friends Escort just got a new engine at ~100k miles. Another co-worker's car (chevy malibu) just needed some sort of fairly significant (~800 bucks) engine work after owning it for 3 months (bought it used). Another's Neon just had a Cam Position Sensor go out, which ended up running ~500 bucks. My parents have had nothing but trouble with their Cadillacs. My brother's Chevies have been maintenance pits (he just bought a Civic last year and has had no problems since).
Of course these may be exceptions to the rule, but every co-worker or neighbor I have that has a Jap car has had close to 0 problems with it over the same time (I say close to, because I can't recall anyone having one, but it's possible). I, myself, have a Saab which has largely been trouble free (new AIR pump, water pump, and an idler pulley, over the course of 100k miles), and a 1977 Dodge van, which is more of a labor of love than reliable transportation (though it is fairly reliable, other than not starting from time to time). I also had a Chevy truck that was very reliable, and after 200k miles finally got a new engine (though it's debatable whether it was necessary or not).
I'm not saying that Toyota or Honda or Mazda are perfect either, but I'll take my chances with them over the Big 3 any day.