Toyota is hands down more reliable than any other manufacturer, as far as I am concerned. Hondas are decent, but they have had a lot of transmission problems in recent years. Nissan is not that great. I had an old Subaru that was pretty decent. Needed some work, but it was a beater. For domestic vehicles, Ford has given me and my family the best reliability. I refuse to buy and Jeep or Chrysler. Those things have had so many issues, and also have a really bad build quality. I see 7-8 year old Chryslers that are all rusted out and the seat are worn out. GM is not that great either.
I work on cars on the side and one thing I will say about Toyota is that they do not use crap materials to build. GMs are horrible to work on. Hard to do anything to a 10 year old one without breaking off a rusty bolt, and they never think about someone having to fix them. Lots of hidden bolts, and access issues on things that are sure to wear out like swaybar link.