At my old house I ran my lawnmower over a yellow jacket nest. Started brushing what I thought were flies off and then once I started to get stung realized what had happened. Ran straight to the house. Ended up with about 20 stings, and one of the lil ****** managed to follow me all the way in the house. I captured him and gave him a slow death. (Jar with a cotton ball soaked in nail polish remover). (old biology class trick) Pretty sure I went through about 20 cans of wasp spray (it was on sale for $1 a can or something at menards) wiping them out.
My dad recently ran over another nest on the same property. He got stung a bunch as well. Went to the same menards, got the same sale 2 years later, and started spraying cans into the hole in the ground. When they started coming out he parked the mower over the hole with the handle tied off and let it run for 15 minutes. Apparently it worked. He emptied another few cans into the hole and put a rock on top just to be sure.