I mean, you're right of course that it could literally happen on any play. If not the end of this game then it could have happened in the first quarter of the next game.
But that just broadens out the point not to necessarily blame it on him playing in a specific quarter and why its important to minimize the number of plays for key players whenever possible as each time the ball is snapped every player has a certain % of risk. Over time, an increased number of plays will result in an increased number of injuries.
(Also, on a less related note, why it can be an advantage for teams in easier conferences that blow through weak competition where they can pull players more regularly, and thus their odds are greater that they enter the postseason with fewer injuries)