IMHO, Cyclone Kool Aid is like fine single malt scotch in that you sip it, not guzzle it. Not trying to pee on your Cheerios here. I know from your posts you are an enthusiastic supporter and an extremely optimist fan. My take is a little more measured and objective after almost 20 years of following along. When ISU first emerged as a program to be noticed and had those Sweet 16 and Elite 8 runs I thought we could build on that and get the recruits that might put us over the top to become an elite program. Never happened and I think now that that lost opportunity is just that, lost. Even when you get to the mountain it can be a quick tumble down again (see Oklahoma). WBB isn't like MBB where there is enough talent to go around and mid majors can Final Four and dance with the blue bloods. The disparity between the elites and the rest of NCAA pack is huge.
I hope we can bounce back to being a true top 25 and build on that. Next years class looks to be a good start on getting our **** together recruiting (maybe two good classes in a row). Assuming no key player quits, we lose only one player but are going to rely heavily on two sophomores and a bunch of freshman. Our next year seniors (taking off the Cyclone tinted glasses) are average Big 12 talent and you can't expect them to suddenly be all Big 12 as seniors. If the freshman prove to be Big 12 ready and if we find a team leader and if no one quits we should be a better team next year and maybe build on that. Best case is that one of the freshman is a team heart and soul type leader and we have a .500+ Big 12.
Of course everything in my mini-ramble here is all just "on paper" speculation. If you want the simple summary than my answer is no, Bill Fennelly will never take us to a Final Four appearance.