Clemson and Notre Dame play on Nov. 7, so one of them is guaranteed a loss. If they both make it unscathed the rest of the way, they'll likely play again in the ACC championship. So you either end up with an unbeaten team and a 2-loss team, or two 1-loss teams whose only loss is to the other one.
"Data points" and "number of conference games" will be the themes in the media if there are hairs to split, if only because that frames the ACC and SEC in a better light. ACC is playing 11 (10+1), while SEC (10+0) and Big 12 (9+1) are playing 10.