It does seem like one may have done it at some point, but I think only four have reached title game.It's kinda wild that a #5 seed has never won it all.
2023: (5) San Diego State loss to (4) UConn
2010: (5) Butler lost to (1) Duke
2002: (5) Indiana lost to (1) Maryland
2000: (5) Florida lost to (1) Michigan State
Three of those four lost to a 1 seed in the championship. Each also defeated a 1 in Sweet 16 (none were able to "coast" by getting a 8/9/16)
