I hope that he won't have to worry about it, but he might. I would guess there is some wiggle room and/or things he could do if he is struggling a bit. He has something like 47 AP/other college credits that may transfer in, but I am not sure how that factors into the GPA requirement, if at all.
That's a lot of credits to bring in and eat up a lot of the early general classes (I'm assuming calculus 1, some history/econ, maybe physics 1).
I brought in a bunch and ended up getting a minor because I needed to get a certain number of hours from ISU and could double count minor classes with major classes.