So here's the new question. Do we take jobs with lesser salaries/new industry to move to Des Moines or do we wait until we find something comparable and stay put until that time?
As long as you can float it I'd get here. My experience in Des Moines is while it's the biggest job market in the state, everything is pretty interconnected. Get here, get involved, work hard and I imagine you'll have plenty of opportunities for upward mobility, either in the company you start at or somewhere else.