I'll second this and add there are some episodes that are pretty bad which is almost always entirely the fault of the guest being a poor conversationalist. I specifically recall the Allison Janney episode being pretty tough to get through.Smartless: Will Arnett, Jason Bateman, and Sean Hayes. Some days I'm in tears from laughing so hard.
That's all to say: if you're considering this podcast, just know a given episode might be bad (it's fairly rare) so try a few other guests before you write it off.
Some of the better ones I recall are Sandra Bullock, George Clooney, and Melissa McCarthy.