Not really. ND v. USC can still be a B1G prime time Saturday night game moving ahead. As can MSU, Michigan, Purdue, etc.
Can they though? The home team is the one that counts in terms of rights fees, isn't it? And if the B1G has the NBC evening window locked up, that means the only way Notre Dame can appear there is if they're on the road, which is outside the NBC Notre Dame contract.