Ozempic, GLP-1 and other modern diabetes / weight loss medications

For those jumping on the peptide train, there is a good review of the state of the industry by "Dr. Mike" Isreatel. Basically, only the GLP stuff has enough literature in human trials to show both safety and effectiveness. Everything else right now is a crapshoot. And he's not only a doctor, but also a bodybuilder who is very open about his past and current steroid use, and he's a proponent of using (proven) substances (responsibly and safely) to improve physique a d performance. If they worked, he'd be taking them himself.


Not to say he isn’t a good authority on the subject, but he has a doctorate, not an MD
 
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Not to say he isn’t a good authority on the subject, but he has a doctorate, not an MD

I think the point is valid there though. The peptide world has a range of products out there, ranging from ones that have been fully tested for safety/efficacy, ones that have just had safety testing, and ones that are 100% experimental. That's not to say they don't work, but very much "use at your own risk and be sure you know what you're getting into".
 
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A very small number of other peptides (mainly BPC-157) have a ton of animal data and of course anecdotal data from humans. I didn't watch "Dr. Mike's" video but there is a vast different between peptides and pharmaceutical drugs. Lastly, there are peptides which can be obtained safely, and others that you can purchase on the gray market (without a prescription, without monitoring from a provider) that I wouldn't get near. Hopefully we see more favorable rulings from the FDA regarding the safety and availability of peptides in general.
 
First off I think it is amazing people trying to get in shape and whatever works works, but I have a question that I have had as someone that did my weight loss the old way of dieting and exercise.

Something that was hounded on me constantly was my protein intake. While i was on a calorie deficit, i had to make sure i was eating enough protein, because your body will burn muscle with the fat if you aren't getting enough fuel. high protein intake helped stem the muscle loss while you lost the fat. I was doing weightlifting with my weight loss because i was aiming at dropping body fat% not just pounds on the scale.

So my question for those that take GLP1, how do you offset muscle loss? From my understanding these drugs just make you feel less hungry and fuller for longer. My main concern would that i wouldn't feel like eating the amount of protein i'd want in a day unless i had a very strict diet.

If anyone would be willing, I'd love to know what your macronutrients look like on a GLP 1 program.
 
First off I think it is amazing people trying to get in shape and whatever works works, but I have a question that I have had as someone that did my weight loss the old way of dieting and exercise.

Something that was hounded on me constantly was my protein intake. While i was on a calorie deficit, i had to make sure i was eating enough protein, because your body will burn muscle with the fat if you aren't getting enough fuel. high protein intake helped stem the muscle loss while you lost the fat. I was doing weightlifting with my weight loss because i was aiming at dropping body fat% not just pounds on the scale.

So my question for those that take GLP1, how do you offset muscle loss? From my understanding these drugs just make you feel less hungry and fuller for longer. My main concern would that i wouldn't feel like eating the amount of protein i'd want in a day unless i had a very strict diet.

If anyone would be willing, I'd love to know what your macronutrients look like on a GLP 1 program.
The males I know have usually hit the weights to try to stem the loss. The women I know, for the most part, drop the weight and then realize they lost muscle mass and then have a doctor tell them they need to eat more protein and lift some. Others are just happy losing weight and move on.

The muscle part seems to be the next hurdle the ones taking the products are finding.
 
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It’s fascinating to revisit those 2024 discussions and realize how much was still under the radar. While the weight loss results were undeniable, the complications for many users went far beyond simple "nausea".
Out of curiosity why do you keep making new accounts and posting this exact thing? Just kinda wondering what agenda you are trying to push here
 
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The males I know have usually hit the weights to try to stem the loss. The women I know, for the most part, drop the weight and then realize they lost muscle mass and then have a doctor tell them they need to eat more protein and lift some. Others are just happy losing weight and move on.

The muscle part seems to be the next hurdle the ones taking the products are finding.
Ok, this was a bit of my fear. I think so many people are focused on seeing the pounds come off but they don't know that they might be losing more than fat. Hence the fear of "Skinny fat" where you are a lower weight but your body fat % is still high because you were losing muscle more than fat.

The only thing i would mention to the guys, you need both lifting and protein. Protein is what maintains the muscle the lifting doesn't stop muscle loss.
 
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Ok, this was a bit of my fear. I think so many people are focused on seeing the pounds come off but they don't know that they might be losing more than fat. Hence the fear of "Skinny fat" where you are a lower weight but your body fat % is still high because you were losing muscle more than fat.

The only thing i would mention to the guys, you need both lifting and protein. Protein is what maintains the muscle the lifting doesn't stop muscle loss.
All of this is explained when the medication is prescribed, it is mandated that individuals participate in strength training to avoid muscle loss and potential risk to cardiovascular heath.

People don’t always follow through but that’s the process. Protein is easily supplemented these days in many forms so even if the appetite isn’t present there are many ways around that if necessary. The dosage can also be adjusted if needed if the weight loss is too rapid
 
not on glp1 but Test has been a life saver for me


I have been on Test for four years. If you are over 40 and have not looked into what your levels are, you should really check it out and see if it's right for you. I love it. I am on the pellets. Which they put in me every 6 months
 
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Ok, this was a bit of my fear. I think so many people are focused on seeing the pounds come off but they don't know that they might be losing more than fat. Hence the fear of "Skinny fat" where you are a lower weight but your body fat % is still high because you were losing muscle more than fat.

The only thing i would mention to the guys, you need both lifting and protein. Protein is what maintains the muscle the lifting doesn't stop muscle loss.
I address this by making sure that the foods I do eat are high protein. Beyond eating meats and nuts that are high protein, I also eat high protein yogurts, drink high protein shakes (that are very low carb, no added sugar) and add protein powder to my morning tea. Weight lifting is also a good option, but from the diet perspective, I have just made a very conscious effort to eat foods that are high protein and lower carb/sugar. It has worked great for me.
 
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I have been on Test for four years. If you are over 40 and have not looked into what your levels are, you should really check it out and see if it's right for you. I love it. I am on the pellets. Which they put in me every 6 months

pellets?! what are you a muscle hamster? I'm doing the 2 week injections like im a junky. its fine
 
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All of this is explained when the medication is prescribed, it is mandated that individuals participate in strength training to avoid muscle loss and potential risk to cardiovascular heath.

People don’t always follow through but that’s the process. Protein is easily supplemented these days in many forms so even if the appetite isn’t present there are many ways around that if necessary. The dosage can also be adjusted if needed if the weight loss is too rapid


Problem with this is people who are generaly on a GLP1 is they were lazy to start and didn't work out. To think they are suddenly going to start working out is a little bit strange. Most likely if they were doing strength training they would not have to go this route. I do calorie drop to lose weight but I slam two Protein drinks a day. One in the morning and one post workout. Just to make sure I am not losing muscle and losing fat. I am at the age where I am not trying to put on more muscle. I don't need gains, I need to stay where I am on muscle. Most people on GLP1 are not going to suddenly do some sort of workout. They are going to sit back, watch TV and lose fat because they have no appetite. Most likely they will be drained of a lot of energy as well from not getting the Nutrients and Protein they should be getting.
 
Problem with this is people who are generaly on a GLP1 is they were lazy to start and didn't work out. To think they are suddenly going to start working out is a little bit strange. Most likely if they were doing strength training they would not have to go this route. I do calorie drop to lose weight but I slam two Protein drinks a day. One in the morning and one post workout. Just to make sure I am not losing muscle and losing fat. I am at the age where I am not trying to put on more muscle. I don't need gains, I need to stay where I am on muscle. Most people on GLP1 are not going to suddenly do some sort of workout. They are going to sit back, watch TV and lose fat because they have no appetite. Most likely they will be drained of a lot of energy as well from not getting the Nutrients and Protein they should be getting.

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Problem with this is people who are generaly on a GLP1 is they were lazy to start and didn't work out. To think they are suddenly going to start working out is a little bit strange. Most likely if they were doing strength training they would not have to go this route. I do calorie drop to lose weight but I slam two Protein drinks a day. One in the morning and one post workout. Just to make sure I am not losing muscle and losing fat. I am at the age where I am not trying to put on more muscle. I don't need gains, I need to stay where I am on muscle. Most people on GLP1 are not going to suddenly do some sort of workout. They are going to sit back, watch TV and lose fat because they have no appetite. Most likely they will be drained of a lot of energy as well from not getting the Nutrients and Protein they should be getting.
I think you would be surprised about this. Often people that go on these meds feel a stronger desire to workout and be active and there are many reasons for this, some we know about and some we still are uncertain as to why.

When people start to see that scale move and feel better it’s pretty great motivation to keep working out and it has a compounding effect. I do agree that certainly not every patient if following these orders but the weight loss makes doing all the training easier (in many areas) and gets people more engaged to stick with it as opposed to the very long journey. Depends on where you start and a bunch of other factors.

One other thing that I like to remind people is the protein isn’t some magic macro that just builds and maintains muscle. It is still caloric consumption that you can over do and lead to weight gain. The vast majority of people who aren’t on a GLP-1 won’t be burning enough fat to make muscle loss a real concern.
 
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I think you would be surprised about this. Often people that go on these meds feel a stronger desire to workout and be active and there are many reasons for this, some we know about and some we still are uncertain as to why.

When people start to see that scale move and feel better it’s pretty great motivation to keep working out and it has a compounding effect. I do agree that certainly not every patient if following these orders but the weight loss makes doing all the training easier (in many areas) and gets people more engaged to stick with it as opposed to the very long journey. Depends on where you start and a bunch of other factors.

One other thing that I like to remind people is the protein isn’t some magic macro that just builds and maintains muscle. It is still caloric consumption that you can over do and lead to weight gain. The vast majority of people who aren’t on a GLP-1 won’t be burning enough fat to make muscle loss a real concern.

I think we might be talking about two different types of people. You have the huge, fat out of shape people who are not going to magically start working out. Then you have the 275 man who does minor workouts that is going to use this product to get back into better shape. The 600 pound types I would bet that 90 percent of them don't see a treadmill in their life, regardless of what weight they get down to. I think the overweight people who have the beer gut looking built might actually start working out after losing some weight to feel better. So yeah it kind of goes both ways.
 
I think we might be talking about two different types of people. You have the huge, fat out of shape people who are not going to magically start working out. Then you have the 275 man who does minor workouts that is going to use this product to get back into better shape. The 600 pound types I would bet that 90 percent of them don't see a treadmill in their life, regardless of what weight they get down to. I think the overweight people who have the beer gut looking built might actually start working out after losing some weight to feel better. So yeah it kind of goes both ways.
Again I think you would he surprised, for a lot of the morbidity obese population working out in a “serious” manor is honestly not recommended. Once that weight comes off and people start to see actual change and feel actual change that motivation changes as well.

Before GLP-1’s not only were people dealing with the food noise but also it just takes a ton of regular consistent work to get any real noticeable results without some help. It’s easy for motivation to die in that instance but we are now getting a ton of reports that people feel a strong desire to exercise on these meds. It’s part of where they get that “miracle” drug designation