A common narrative about Matt Campbell is his winless record vs Iowa. I will point out that Paul freaking Rhoads who ran an inferior ISU program went 3-4 vs Iowa... so **** happens.
One edge I give Iowa is Ferentz's experience. While schematically the offenses/teams are different, the similarity between Campbell and Ferentz is to burn clock and rely on bend/don't break defense. Campbell has become more confident/comfortable in that approach in recent years. Also helps that ISU finally has a good run blocking unit to combat what is usually a strength Iowa has. I think ISU wins this year. Perhaps close for 2-3 qtrs, but ISU pulls away.
I'm curious to see how the receivers progress in 2021. ISU wasn't very explosive in the air. Partially not needing to be, but would like to see that develop into a bit more dangerous attack.