I don't think coaches have figured anything out really. One of the nice things about Fred's offense is that it is adaptable to adjustments in the defense as long as the basic rules of it are followed.
I think the biggest problems since conference started are the lack of rebounding, the interior defense, and the lack of offensive spacing and ball movement. In the non-conference games, ISU established itself as one of the better rebounding teams in the country. Even in their non-conference losses, ISU either won the rebounding battle, or kept it very close. That has not been the case in the conference games. In the 5 games, ISU has won the rebounding once (TCU), tied once (Texas) and lost the other three. In particular, they seem to give up a lot of offensive rebounds and second opportunities which can cause problems.
The interior defense has not been strong in conference. It seems ISU cannot defend on the inside without fouling, which as we saw last night can lead to personnel problems. I think every college team needs one good shot blocker, if at all possible. I'm not sure ISU has had one since Cato was here.
Finally, ISU was one of the highest scoring teams in the country in the non-conference. That was done with excellent spacing and rapid ball movement which resulted often in good open looks. Teamwork. You can see it by watching, but you can also see it in the stats by the number of assists compared to the number of made baskets. Our of conference, the percentage of made baskets which had an assist was very high. During conference...it is not very good. It seems like ISU is reverting back to the individual play in conference, and that just is not going to win many games.