The problem is there is too much speed on defense. In college, Oregon's offense works because they spread the D and expose weaknesses (slower players, big guys in space, etc.). In the NFL it is hard to do that because the guys on D are just as fast or faster than the skill players they are defending.
Just for reference, you said use McCluster and Charles like Oregon does. McCluster ran a 4.58 40 yard dash, Charles ran a 4.38. Look at guys like Patrick Willis (4.51) Brian Cushing (4.57) Von Miller (4.49) and even a huge guy like JJ Watt (4.81) and compare those to any team Oregon plays (say Cal for now) whose 2 outside linebackers run a 4.77 and a 4.98.
I know thats just going off 40 which obviously doesn't perfectly translate to everything on the football field. But when you have athletes, that are basically the cream of the NCAA crop every year, starting at every position on the field in the NFL, a system like that just doesn't seem to translate.